HLA-E antibody [MEM-E/06]

GeneTex

HLA-E antibody [MEM-E/06]

9

This antibody reacts with some classical MHC Class I molecules (HLA-A3, -A11, -B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader cross-reactivity c

Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

MEM-E/06

1 mg/ml

Unconjugated

HLA-E

major histocompatibility complex, class I, E

HLA class I histocompatibility antigen, alpha chain E; HLA-6.2; MHC class I antigen E; MHC class Ib antigen; QA1

Mouse

IgG1

HLA class I histocompatibility antigen, alpha chain E

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Human, Primate

2°C to 8°C

12352203