HM13 Antibody

Cusabio

HM13 Antibody

20

ImmunoFluorescence, Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

HM13

histocompatibility minor 13

H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1, signal peptide peptidase, intramembrane protease 1, minor histocompatibility antigen 13, minor histocompatibility antigen H13, presenilin-like protein 3, signal peptide peptidase beta, signal peptide peptidase like 1

Rabbit

IgG

Signal peptide peptidase

Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).

Human, Mouse

-20°C or -80°C

41116161