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ProductsBack/HMGCR antibody, Internal
The data was published in the journal Sci Rep in 2017.PMID: 28831159
The data was published in the journal Sci Rep in 2017.PMID: 28831159
The data was published in the journal Sci Rep in 2017.PMID: 28831159

HMGCR antibody, Internal

GTX88456
GeneTex
ApplicationsWestern Blot
DownloadDatasheet
Product group Antibodies
TargetHMGCR
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Overview

  • Supplier
    GeneTex
  • Product Name
    HMGCR antibody, Internal
  • Delivery Days Customer
    9
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.50 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3156
  • Target name
    HMGCR
  • Target description
    3-hydroxy-3-methylglutaryl-CoA reductase
  • Target synonyms
    3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; LDLCQ3
  • Host
    Goat
  • Isotype
    IgG
  • Protein IDP04035
  • Protein Name
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • Scientific Description
    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Phospholipase D2 loss results in increased blood pressure via inhibition of the endothelial nitric oxide synthase pathway. Nelson RK et al., 2017 Aug 22, Sci Rep
    Read more
  • Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Lai YS et al., 2014 Jun 25, J Agric Food Chem
    Read more

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Figure 1. Western blot analysis of HMGCR using anti-HMGCR antibody (A00643-3). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human CACO-2 whole cell lysates, Lane 2: human RT4 whole cell lysates, Lane 3: human THP-1 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HMGCR antigen affinity purified polyclonal antibody (Catalog # A00643-3) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for HMGCR at approximately 97 kDa. The expected band size for HMGCR is at 97 kDa.
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