WB analysis of (A) normal human plasma, (B) HMWK-deficient plasma, and (C) purified HMWK proteins using GTX21004 HMW Kininogen antibody [C11C1].
WB analysis of (A) normal human plasma, (B) HMWK-deficient plasma, and (C) purified HMWK proteins using GTX21004 HMW Kininogen antibody [C11C1].
HMW Kininogen antibody [C11C1]
GTX21004
Overview
- SupplierGeneTex
- Product NameHMW Kininogen antibody [C11C1]
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes an epitope on the unique 46kDa light chain of human HMWK. The epitope maps to domain 5 of human HMWK. It can completely neutralize the coagulant activity of human HMWK.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDC11C1
- ConjugateUnconjugated
- Gene ID3827
- Target nameKNG1
- Target descriptionkininogen 1
- Target synonymsalpha-2-thiol proteinase inhibitor; BDK; BK; bradykinin; fitzgerald factor; HAE6; high molecular weight kininogen; HMWK; kininogen-1; KNG; williams-Fitzgerald-Flaujeac factor
- HostMouse
- IsotypeIgG1
- Protein IDP01042
- Protein NameKininogen-1
- Scientific DescriptionThis gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203