HNMPA-(AM)3

MedChem Express

HNMPA-(AM)3 [120944-03-8]

10

120944-03-8

Research Use Only

97.22

C20H23O10P

454.36

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 microM) and insulin receptor activity (IC50 is 14.2 microM and 200 microM in mosquitoes and mammals, respectively)[1][2].

CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O

2°C to 8°C

12352200