hNTS1R agonist-1

MedChem Express

hNTS1R agonist-1

14

Research Use Only

C37H62N10O9

790.95

hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinsons disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent[1].

O=C([C@H]1N(CCC1)C([C@H](CCONC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)=O)CC2=CC=C(O)C=C2

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