HNW005

MedChem Express

HNW005

5

Research Use Only

C18H12F3N3O3

375.30

HNW005 is a dual inhibitor of NLRP3 inflammasome and urate transporter 1 (URAT1). It has a KD value of 204.6 nM and an IC50 of 1.7 microM for inhibiting NLRP3 inflammasome activation, and an IC50 of 6.4 microM for inhibiting uric acid transmembrane transport. When administered at a dose of 2 mg/kg in vivo, HNW005 can achieve a uric acid reduction rate of 64.8%. It can exert anti - inflammatory, analgesic, and uric acid - lowering activities by inhibiting the activation of NLRP3 inflammasome and uric acid transmembrane transport. HNW005 can be used in the research of gouty arthritis[1].

O=C(NC1=CC=CC=C1C(O)=O)C2=NNC(C3=CC=C(C(F)(F)F)C=C3)=C2

12352200