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CgoaEGY7Lx6ETR-_AAAAAMLqj0o216.png
CgoaEGY7Lx6ETR-_AAAAAMLqj0o216.png
CgoaEGY7Lx6ETR-_AAAAAMLqj0o216.png

HPK1-IN-22 [2380300-79-6]

Research Use Only
T62927
TargetMol Chemicals
CAS Number2380300-79-6
Product group Chemicals
Molecular Weight462.61
Price on request
Packing Size
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    HPK1-IN-22 [2380300-79-6]
  • Delivery Days Customer
    14
  • CAS Number
    2380300-79-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    HPK1-IN-22
  • Molecular Formula
    C26H30N4O2S
  • Molecular Weight
    462.61
  • Scientific Description
    HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine 376) and promotes anti-cancer immune responses. HPK1-IN-22 inhibits tumor growth and increases intra-tumor infiltration of DCs, NK cells and CD107a+CD8+ T cells, but decreases infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells and LAG3+CD8+ T cells in a 4T-1 homozygous mouse model.
  • Shelf life instruction
    3 years
  • SMILES
    CN1CCC(CC1)c1ncc(s1)-c1cnc(N)c(OCc2cccc(c2)C#CC(C)(C)O)c1
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000