HPK1-IN-22

TargetMol Chemicals

HPK1-IN-22

14

2380300-79-6

Chemical

HPK1-IN-22

C26H30N4O2S

462.61

HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine 376) and promotes anti-cancer immune responses. HPK1-IN-22 inhibits tumor growth and increases intra-tumor infiltration of DCs, NK cells and CD107a+CD8+ T cells, but decreases infiltration of T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells and LAG3+CD8+ T cells in a 4T-1 homozygous mouse model.

3 years

O(CC1=CC(C#CC(C)(C)O)=CC=C1)C2=CC(C=3SC(=NC3)C4CCN(C)CC4)=CN=C2N

-20°

12352200