HPK1-IN-33 [2920000-86-6]

TargetMol Chemicals

HPK1-IN-33 [2920000-86-6]

86

Chemical

Research Use Only

HPK1-IN-33

C18H16ClFN6

370.81

HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cells and >10000 nM in Jurkat HPK1 KO cells [1].

3 years

N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1

-20°C

51202000