HPK1-IN-40-d2

MedChem Express

HPK1-IN-40-d2

14

Research Use Only

C24H20D2FN7O3

477.49

HPK1-IN-40 (compound 49) is a potent and selective HPK1 inhibitor with an IC50 of 0.9 nM. HPK1-IN-40 reinvigorates T-cell receptor (TCR) signaling, promoting T-cell function and cytokine production in T cells while having anti-cancer activity[1].

OC([2H])([C@@H](NC1=NC(NC2=CC(C(C)(N3)C)=C(C=C2)C3=O)=NC=C1C4=NN=CO4)C5=CC=C(C=C5)F)[2H]

12352200