HPK1-IN-43

MedChem Express

HPK1-IN-43

5

Research Use Only

C26H25F3N6O2

510.51

HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). HPK1-IN-43 can be used in cancer research[1].

O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=NC(NC4=C(OC)C=C(CCN(C)C5)C5=C4)=NC=C3C(N)=C1

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