HPK1-IN-48

MedChem Express

HPK1-IN-48

5

Research Use Only

C33H38N8O3

594.71

HPK1-IN-48 (compound 14g) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a IC50 of 0.15 nM. HPK1-IN-48 significantly suppresses the phosphorylation of SLP76 with a IC50 of 27.92 nM[1].

COC1=C(C=CC(N2CC(N(C(C2)C)C)C)=C1)NC3=C(C=NC(NC4=CC=C(C=C4)C(NCC5=CC=CC=C5)=O)=N3)C(N)=O

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