HS-345

MedChem Express

HS-345

9

Research Use Only

C19H18N6O2S

394.45

HS-345 is a TrkA/Ak inhibitor with significant anti-pancreatic cancer effects. HS-345 inhibits the growth and proliferation of pancreatic cancer cells by targeting the TrkA/Akt signaling pathway, while also inducing apoptosis. Additionally, HS-345 suppresses blood vessel formation by decreasing the expression of HIF-1alpha and VEGF. HS-345 holds promise for research in pancreatic cancer[1].

O=S(C1=CC(C2=CN=C(NC=C3C4=CC=NC=C4)C3=C2)=CN=C1N)(N(C)C)=O

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