hSMG-1 inhibitor 11e

MedChem Express

hSMG-1 inhibitor 11e [1402452-10-1]

10

1402452-10-1

Research Use Only

99.81

C26H27N7O3S

517.60

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC 50 of 900-fold selectivity over mTOR (IC 50 of 45 nM), PI3Kalpha/gamma (IC 50 s of 61 nM and 92 nM) and CDK1/CDK2 (IC 50 s of 32 microM and 7.1 microM) [1] .

O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1C)(N(C)C)=O

2°C to 8°C

12352200