HSP90-IN-11

MedChem Express

HSP90-IN-11 [2986564-20-7]

10

Research Use Only

C27H30FN3O6

511.54

HSP90-IN-11 (Compound 12c) is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90alpha inhibition comparable to AUY-922 (Luminespib). HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population[1].

CCN(C1=CC=C(C=C1)CN2C(C(F)=CN(C2=O)C3CCCO3)=O)C(C4=CC(C(C)C)=C(C=C4O)O)=O

12131703