HSP90-IN-12 [2408643-60-5]

MedChem Express

HSP90-IN-12 [2408643-60-5]

10

2408643-60-5

Research Use Only

C25H36O4

400.55

Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C

12131703