HSP90-IN-33

MedChem Express

HSP90-IN-33

9

Research Use Only

C21H25Cl2N5O2

450.36

HSP90-IN-33 (compound 24e) is a potent Hsp90 inhibitor with Kd values of ≥200, 7.3 microM for Hsp90alpha, Hsp90beta, respectively. HSP90-IN-33 induces apoptosis and cell cycle arrest at G0/G1 phase. HSP90-IN-33 decreases the protein expression of ERalpha, CDK4 and Akt[1].

O=C(C1=C(Cl)C(Cl)=C(C)N1)NC2=CC=C(C(N)=O)C=C2N3CC4(CN(C)CC4)CC3

12352200