Hsp90-IN-42

MedChem Express

Hsp90-IN-42

999

Research Use Only

C27H27FN2O2

430.51

Hsp90-IN-42 (Compound 13l) is a potent heat shock protein 90 (Hsp90) inhibitor (IC50=15.65 nM). Hsp90-IN-42 reduces the stability of the epidermal growth factor receptor (EGFR), suppressing the activation of the EGFR-Akt signaling pathway, inducing G0/G1 phase arrest in colorectal cancer cells (such as HT-29 cells), and slightly triggering apoptosis. Hsp90-IN-42 also inhibits cell proliferation and migration by down-regulating the expression of CDK12, CDK13, and Bcl-2 proteins, and up-regulating the expression of Bax protein. Hsp90-IN-42 is promising for research of colorectal cancer[1].

O=C(NC1=CC=C(F)C=C1)C2=CC=C(O[C@@H]3CN(CC4=CC=CC=C4)[C@]5([H])CC[C@@]3([H])C5)C=C2

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