Human c-Met Protein (Recombinant His) (Met1-Thr932)

LifeSpan BioSciences

Human c-Met Protein (Recombinant His) (Met1-Thr932)

23

Research Use Only

>90%

MET

MET proto-oncogene, receptor tyrosine kinase

AUTS9, DA11, DFNB97, HGFR, RCCP2, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met

The mature form of recombinant human c-Met is a disulfide-linked heterodimer composed of proteolytically cleaved a and Beta subunits. Each a and Beta subunit together consists of 919 amino acids and has a predicted molecular mass of 103 (a=33 +Beta=70) kDa. As a result of glycosylation, rh c-MET heterodimer thus migrates with apparent molecular mass of approximately 45 kDa and 85 kDa respectively in SDS-PAGE under reducing conditions. A DNA sequence encoding the extracellular domain of human c-Met (NP_000236) (Met 1-Thr 932) was fused with a polyhistidine tag at the C-terminus.

-80°C

41116100

Human