Human CCL4 / MIP1 beta ELISA Kit

Arigo Biolaboratories

Human CCL4 / MIP1 beta ELISA Kit

23

ELISA

Intra-Assay CV: less than 10%Inter-Assay CV: less than 10%

1 pg/ml

3.5 hours

Research Use Only

HRP

C-C motif chemokine 4

CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.

2°C to 8°C

41116100

Human