Human CD255 / TWEAK recombinant protein (Active) (His-tagged, C-ter)

Arigo Biolaboratories

Human CD255 / TWEAK recombinant protein (Active) (His-tagged, C-ter)

23

Other Application

Research Use Only

>98%

TNFSF12

TNF superfamily member 12

APO3L, DR3LG, TNF12, TNLG4A, TWEAK, tumor necrosis factor ligand superfamily member 12, APO3 ligand, APO3/DR3 ligand, TNF-related WEAK inducer of apoptosis, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor superfamily member 12

Tumor necrosis factor ligand superfamily member 12

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

-20°C

41116120

Human