Human Cytokeratin 8 Ready-To-Use IHC Kit

Bioss Antibodies

Human Cytokeratin 8 Ready-To-Use IHC Kit

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ImmunoHistoChemistry

Research Use Only

Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.

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