Human EGFRVIII Protein (EG8-HM154)

KACTUS

Human EGFRVIII Protein (EG8-HM154)

9

Research Use Only

>95%

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

-20°C or -80°C,-80°C

12352202