Human ERBB4 / HER4 ELISA Kit

Arigo Biolaboratories

Human ERBB4 / HER4 ELISA Kit

23

ELISA

31.2 pg/ml - 2,000 pg/ml

Intra-Assay CV: 4.5%Inter-Assay CV: 5.3%

13 pg/ml

~ 5 hours

Research Use Only

HRP

Receptor tyrosine-protein kinase erbB-4

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

2°C to 8°C

41116100

Human