Human IDH1 Protein (IDH-HE101)

KACTUS

Human IDH1 Protein (IDH-HE101)

9

Research Use Only

>95%

Isocitrate dehydrogenase [NADP] cytoplasmic

Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG). Genetic gain-of-function mutations in IDH1 and IDH2 confer a neomorphic activity that allow reduction of alpha -KG to (R)-2- hydroxyglutarate, the accumulation of which results in the development of cancers like low grade gliomas and leukemia.Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer.

-80°C

12352202