Human IGFBP-3R Protein (IGF-HM23R)

KACTUS

Human IGFBP-3R Protein (IGF-HM23R)

9

Research Use Only

>95%

Insulin-like growth factor-binding protein 3 receptor

Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-kappaB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

-20°C or -80°C,-80°C

12352202