Human IL-1B / IL-1 Beta Protein (Recombinant)

LifeSpan BioSciences

Human IL-1B / IL-1 Beta Protein (Recombinant)

23

Research Use Only

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Interleukin-1 beta (rhIL-1Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.Recombinant human Interleukin-1 beta (rhIL-1Beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rhIL-1Beta has a molecular mass of 17.3kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

-20°C,-80°C,2°C to 8°C

12352202