WB analysis of GTX00088-pro Human IL15 protein (active).
Human IL15 protein (active)
GTX00088-PRO
ApplicationsFunctional Assay
Product group Proteins / Signaling Molecules
Protein IDP40933
Overview
- SupplierGeneTex
- Product NameHuman IL15 protein (active)
- Delivery Days Customer9
- ApplicationsFunctional Assay
- CertificationResearch Use Only
- ConjugateUnconjugated
- Protein IDP40933
- Protein NameInterleukin-15
- Scientific DescriptionThe protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each others activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352202