Human IL17B protein, His tag (active)

GeneTex

Human IL17B protein (active)

9

IL17B (Interleukin-17B) is is a T cell-derived cytokine that shares sequence similarity with IL17, which has been proven to mediate potent inflammatory immune response. Besides, increasing evidence suggests that IL17 may play a critical role in various kinds of liver diseases, including hepatocellualar carcinoma. Thus a stimulation assay has been conducted to detect the bioactivity of IL17B. HepG2 cells were seeded into 24-well plate at a density of 1x105 cells/ml, and allowed to attach overnight before treated with or without certain concentrations (250 ng/ml, 500 ng/ml) of IL17B for 20h and IL-8 levels in the cell supernatant were determined by ELISA.

Functional Assay

Research Use Only

Unconjugated

Interleukin-17B

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

-20°C or -80°C,2°C to 8°C

12352202