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Human Immunoglobulin Alpha (IgA) Heavy Chain(rHISA43), CF405S conjugate, 0.1mg/mL [26628-22-8]

Human Immunoglobulin Alpha (IgA) Heavy Chain(rHISA43), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC043876
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetIGHA1
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Overview

  • Supplier
    Biotium
  • Product Name
    Human Immunoglobulin Alpha (IgA) Heavy Chain(rHISA43), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    rHISA43
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID3493
  • Target name
    IGHA1
  • Target description
    immunoglobulin heavy constant alpha 1
  • Target synonyms
    IgA1; immunoglobulin alpha 1; immunoglobulin heavy chain constant region alpha 1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP01876
  • Protein Name
    Immunoglobulin heavy constant alpha 1
  • Scientific Description
    This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkins lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203