Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-HM1A1)

KACTUS

Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-HM1A1)

9

Research Use Only

>95%

Integrin alpha1beta1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen-binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin alpha1beta1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.

-20°C or -80°C,-80°C

12352202