Human Kappa Light Chain / IGKC (B-Cell Marker)(KLC2886R), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

Human Kappa Light Chain / IGKC (B-Cell Marker)(KLC2886R), CF594 conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

KLC2886R

0.1 mg/ml

Other Conjugate

IGKC

immunoglobulin kappa constant

HCAK1; IGKCD; immunoglobulin kappa (invariant region); immunoglobulin kappa constant region; immunoglobulin kappa light chain (VJ); Km

Rabbit

IgG

Immunoglobulin kappa constant

This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Rabbit

2°C to 8°C

12352203