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Human LAIR-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human LAIR-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human LAIR-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)

Research Use Only
LA1-H5252
ACRObiosystems
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    ACRObiosystems
  • Product Name
    Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
  • Delivery Days Customer
    4
  • Category Supplier
    Immune Checkpoint Proteins
  • Certification
    Research Use Only
  • Estimated Purity
    95%
  • Format
    Powder
  • Scientific Description
    Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
  • Shelf life instruction
    ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Source
    Human LAIR-1, Fc Tag (LA1-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 163 (Accession # Q6GTX8-1).
  • Storage Instruction
    -20℃
  • UNSPSC
    12352202