Human LDL receptor ELISA Kit

Arigo Biolaboratories

Human LDL receptor ELISA Kit

23

ELISA

Intra-Assay CV: 6.1%; Inter-Assay CV: 6.6%

31.25 pg/ml

There is no detectable cross-reactivity with other relevant proteins.

~ 5 hours

Research Use Only

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

2°C to 8°C

41116133