Human MMP2 Assay Kit

Arigo Biolaboratories

Human MMP2 Assay Kit

23

Functional Assay

16 - 16000 pg/ml

40 pg/ml for 2 hours incubation20 pg/ml for 6 hours incubation4 pg/ml for overnight incubation

Measures endogenous active MMP2 (naturally occurring) or total active MMP2 (following activation with APMA).

Overnight

Research Use Only

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

-20°C

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