The protein activity of GTX01279-pro Human PD-L1 protein was measured by its ability to inhibit anti-CD3 antibody (2 microg/ml) induced IL-2 secretion in human T lymphocytes. ED?? : 0.4-3 microg/ml
The protein activity of GTX01279-pro Human PD-L1 protein was measured by its ability to inhibit anti-CD3 antibody (2 microg/ml) induced IL-2 secretion in human T lymphocytes. ED?? : 0.4-3 microg/ml
Human PD-L1 protein, mouse IgG1 Fc tag (active)
GTX01279-PRO
ApplicationsFunctional Assay
Product group Proteins / Signaling Molecules
Protein IDQ9NZQ7
Overview
- SupplierGeneTex
- Product NameHuman PD-L1 protein, mouse IgG1 Fc tag (active)
- Delivery Days Customer9
- ApplicationsFunctional Assay
- CertificationResearch Use Only
- ConjugateUnconjugated
- Protein IDQ9NZQ7
- Protein NameProgrammed cell death 1 ligand 1
- Scientific DescriptionThis gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- Storage Instruction-20°C
- UNSPSC12352202