Human R-Spondin 1 / RSPO1 (21-146) Protein, His Tag, premium grade

ACRObiosystems

Human R-Spondin 1 / RSPO1 (21-146) Protein, His Tag, premium grade

4

Bio-Markers & CD Antigens

Research Use Only

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.6 kDa. The protein migrates as 20-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

-20℃

41116133