Human recombinant HMGB1 (High mobility group box 1) protein, AF

Boster Bio

Human recombinant HMGB1 (High mobility group box 1) protein, AF

9

Other Application

Research Use Only

>98%

High mobility group protein B1

High mobility group protein B1 protein (HMGB1) is the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 25 kDa single chain polypeptide containing three domains: two N-terminal HMG boxes A and B, and a negatively charged 30 aa C-terminal region that contains only Asp and Glu. Post-translational modification on HMGB1 have been reported, affect its localization, receptor interactions, and function. HMGB1, with a disulfide bond between C23 and C45, that cause cytokine production and the activation of NF-kappaB. Otherwise, the fully oxidized form has no immune function, losing its proinflammatory effect and the apoptotic cell death activation function.

E.coli

-20°C,-20°C or -80°C,2°C to 8°C

12352202