3 microg of GTX67159-pro Human Sorbitol Dehydrogenase protein (active) by SDS-PAGE under reducing condition and visualized by coomassie blue stain
3 microg of GTX67159-pro Human Sorbitol Dehydrogenase protein (active) by SDS-PAGE under reducing condition and visualized by coomassie blue stain
Human Sorbitol Dehydrogenase protein, His tag (active)
GTX67159-PRO
Product group Molecular Biology
Overview
- SupplierGeneTex
- Product NameHuman Sorbitol Dehydrogenase protein (active)
- Delivery Days Customer9
- Application Supplier NoteSpecific activity is > 20000 pmol/min/microg, and is defined as the amount of enzyme that catalyze D-fructose to D-sorbitol per minute at pH 7.5 at 37C.
- CertificationResearch Use Only
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Scientific DescriptionSorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352204