3microg Human Thymidylate synthase protein (GTX67911-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
3microg Human Thymidylate synthase protein (GTX67911-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Human Thymidylate synthase protein, His tag
GTX67911-PRO
Product group Molecular Biology
Overview
- SupplierGeneTex
- Product NameHuman Thymidylate synthase protein
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Scientific DescriptionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352204