3μg Human TPMT protein (GTX67901-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
3μg Human TPMT protein (GTX67901-pro) by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Human TPMT protein
GTX67901-PRO
Protein IDQ9BS45
Product group Proteins / Signaling Molecules
Overview
- SupplierGeneTex
- Product NameHuman TPMT protein
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID7172
- Target nameTPMT
- Target descriptionthiopurine S-methyltransferase
- Target synonymsTPMTD, thiopurine S-methyltransferase, S-adenosyl-L-methionine:thiopurine S-methyltransferase
- Protein IDQ9BS45
- Protein NameThiopurine S-methyltransferase
- Scientific DescriptionThis gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC41115809
- SpeciesHuman