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Human TRAIL R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human TRAIL R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human TRAIL R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag

Research Use Only
TR1-H5228
ACRObiosystems
Product group Molecular Biology
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Overview

  • Supplier
    ACRObiosystems
  • Product Name
    Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
  • Delivery Days Customer
    4
  • Category Supplier
    Bio-Markers & CD Antigens
  • Certification
    Research Use Only
  • Scientific Description
    Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.8 kDa. The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
  • Shelf life instruction
    ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  • Storage Instruction
    -20℃
  • UNSPSC
    41116133