hURAT1 inhibitor 1

MedChem Express

hURAT1 inhibitor 1

9

Research Use Only

C24H19BrO4

451.31

hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC 50 s of 0.16 microM and 4.47 microM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics [1] .

C/C(C(O)=O)=C/CC1=C2C(C(CC(C3=C(C=CC=C4)C4=C(Br)C=C3)O2)=O)=CC=C1

12352200