HUWE1 Polyclonal Antibody

Reddot Biotech

HUWE1 Polyclonal Antibody

5

0.8 mg/ml

HUWE1

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECTH9; HECT-type E3 ubiquitin transferase HUWE1; homologous to E6AP carboxyl terminus homologous protein 9; HSPC272; Ib772; large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; MRXST; MULE; upstream regulatory element-binding protein 1; UREB1; URE-B1; URE-binding protein 1

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.

-20°C

12352203