HX531

MedChem Express

HX531 [188844-34-0]

10

188844-34-0

Research Use Only

99.87

C29H29N3O4

483.56

HX531 is an effective RXR antagonist with oral activity, with an IC 50 of 18 nM, with activity against black melanoma. HC531 can eliminate the anti- apoptotic effects of all-trans-retinoic acid (t-RA) and exerts anti-obesity and anti-diabetic effects through leptin-dependent pathways and the p53-p21Cip1 pathway, resulting in G0/G1 cell cycle arrest [1] [2] [3] .

O=C(O)C1=CC=C(C2=NC3=CC([N+]([O-])=O)=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1

-20°C,2°C to 8°C

12352200