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ProductsBack/Hymenidin [107019-95-4]
Chemical Structure
Chemical Structure
Chemical Structure

Hymenidin [107019-95-4]

Research Use Only
AG-CN2-0503
AdipoGen Life Sciences
CAS Number107019-95-4
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight310.2 . 18.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Hymenidin
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    107019-95-4
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C11H12BrN5O . H2O
  • Molecular Weight
    310.2 . 18.0
  • Scientific Description
    Chemical. CAS: 107019-95-4. Formula: C11H12BrN5O . H2O. MW: 310.2 . 18.0. Isolated from sponge Stylissa sp. Inhibitor of CDK5/p25 (IC50=4microM) and GSK-3beta (IC50=12microM). Potentially useful in neuronal diseases research. Antagonist of serotonergic receptors. Shown to reduce voltage-dependent calcium elevation. Moderate anticancer compound. Inhibits cell growth in a panel of cancer cell lines at low microM range. Antiprotozoal agent. Antibacterial. Plays a role in the sponge antibacterial defense. - Inhibitor of CDK5/p25 (IC50=4microM) and GSK-3beta (IC50=12microM). Potentially useful in neuronal diseases research. Antagonist of serotonergic receptors. Shown to reduce voltage-dependent calcium elevation. Moderate anticancer compound. Inhibits cell growth in a panel of cancer cell lines at low microM range. Antiprotozoal agent. Antibacterial. Plays a role in the sponge antibacterial defense.
  • SMILES
    O=C(NC/C=C/C1=CN=C(N)N1)C2=CC(Br)=CN2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 3462
  • UNSPSC
    12352200

References

  • A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp: J. Kobayashi, et al.; Experientia 42, 1176 (1986)
  • Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000)
  • Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation: U. Bickmeyer, et al.; Toxicon 44, 45 (2004)
  • Marine compounds for the therapeutic treatment of neurological disorders: D. Alonso, et al.; Expert Opin. Ther. Pat. 15, 1377 (2005)
  • Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A: G.R. Pettit, et al.; Oncol. Res. 15, 11 (2005)
  • Bromopyrrole alkaloids as lead compounds against protozoan parasites: F. Scala, et al.; Mar. Drugs 8, 2162 (2010)
  • Chemical defense against predators and bacterial fouling in the Mediterranean sponges Axinella polypoides and A. verrucosa: M. Haber, et al.; MEPS 422, 113 (2011)