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ProductsBack/I-BET762 [1260907-17-2]

I-BET762 [1260907-17-2]

Research Use Only
SYN-3033
SYNkinase
CAS Number1260907-17-2
Product group Chemicals
Estimated Purity>95%
Molecular Weight423.9
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Overview

  • Supplier
    SYNkinase
  • Product Name
    I-BET762 [1260907-17-2]
  • Delivery Days Customer
    10
  • CAS Number
    1260907-17-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C22H22ClN5O2
  • Molecular Weight
    423.9
  • Scientific Description
    Chemical. CAS: 1260907-17-2. Formula: C22H22ClN5O2. MW: 423.9. I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762 disrupts the formation of the chromatin complexes essential for expression of inflammatory genes. - I-BET762 (GSK525762A) is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4. It binds to the tandem bromodomains of BET with a Kd of 50.5-61.3nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5nM in FRET analysis. I-BET762 disrupts the formation of the chromatin complexes essential for expression of inflammatory genes.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000