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I-CBP112 (hydrochloride)

HY-19541A
MedChem Express
CAS Number2147701-33-3
Product group Chemicals
Molecular Weight505.05
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Overview

  • Supplier
    MedChem Express
  • Product Name
    I-CBP112 (hydrochloride) [2147701-33-3]
  • Delivery Days Customer
    10
  • CAS Number
    2147701-33-3
  • Certification
    Research Use Only
  • Molecular Formula
    C27H37ClN2O5
  • Molecular Weight
    505.05
  • Scientific Description
    I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin[1].
  • SMILES
    CCC(N1CCOC2=C(OC[C@@H]3CN(C)CCC3)C=C(C4=CC=C(OC)C(OC)=C4)C=C2C1)=O.[H]Cl
  • UNSPSC
    12352200

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