I-CBP112 (hydrochloride)
HY-19541A
Overview
- SupplierMedChem Express
- Product NameI-CBP112 (hydrochloride) [2147701-33-3]
- Delivery Days Customer10
- CAS Number2147701-33-3
- CertificationResearch Use Only
- Molecular FormulaC27H37ClN2O5
- Molecular Weight505.05
- Scientific DescriptionI-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin[1].
- SMILESCCC(N1CCOC2=C(OC[C@@H]3CN(C)CCC3)C=C(C4=CC=C(OC)C(OC)=C4)C=C2C1)=O.[H]Cl
- UNSPSC12352200