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Chemical Structure
Chemical Structure
Chemical Structure

Ibrutinib

AG-CR1-3620
AdipoGen Life Sciences
CAS Number936563-96-1
Product group Chemicals
Estimated Purity>98%
Molecular Weight440.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ibrutinib
  • Delivery Days Customer
    10
  • CAS Number
    936563-96-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger
  • Molecular Formula
    C25H24N6O2
  • Molecular Weight
    440.5
  • Scientific Description
    Chemical. CAS: 936563-96-1. Formula: C25H24N6O2. MW: 440.5. Potent and highly selective Brutons tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM). - Potent and highly selective Brutons tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).
  • SMILES
    NC1=C2C(=NC=N1)N(N=C2C1=CC=C(OC2=CC=CC=C2)C=C1)C1CCCN(C1)C(=O)C=C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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